The epithelial Na+ channel UNC-8 promotes an endocytic mechanism that recycles presynaptic components to new boutons in remodeling neurons
Summary: Circuit refinement involves the formation of new presynaptic boutons as others are dismantled.Nascent presynaptic sites can incorporate material from recently eliminated synapses, but the recycling mechanisms remain elusive.In early-stage C.elegans larvae, the presynaptic boutons of GABAergic DD neurons are removed and new outputs establis